Matrigel: basement membrane matrix with biological activity.

By H. Kleinman, G. Martin. Seminars in Cancer Biology, 2005

1,686 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/25d49e583517d5fda6cb8ea10693deab51e56db0

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Citations in the corpus

Modeling tissue morphogenesis and cancer in 3D. (2007, positive): “For growth and differentiation of epithelial cells, however, reconstituted gels of an extract containing basement membrane components and growth factors termed Matrigel (or EHS matrix or Cultrex) are much more effective (Kleinman and Martin, 2005).”
Three-Dimensional Cell Culture Matrices: State of the Art (2008, background): “These soluble proteins undergo self-assembled polymerization when incubated at 378C, forming a 3D gel.(108) AlthoughMatrigel is an excellent biomaterial because of its abundance of natural biological molecules, its heterogeneous and unidentified molecular components reduce a degree of experimental c”
A practical guide to hydrogels for cell culture (2016, methodology): “Matrigel is a basement membrane– derived preparation extracted from Engelbreth–Holm–Swarm (EHS) mouse sarcoma tumors that is composed primarily of laminin, type IV collagen, and entactin, with various other constituents including proteoglycans and growth factors 49 .”
Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. (2010, positive): “Currently, in vitro 3D culture models for cancer research include multicellular spheroids grown in suspension [11, 12] and cells embedded within naturally derived extracellular matrices (ECM) (e.g. reconstituted ECM-protein-based matrices for MatrigelTM [13-17], collagen gels [18, 19] and cell-secre”
Design properties of hydrogel tissue-engineering scaffolds (2011, background): “consisting of laminin, collagen type IV, enlactin and various GFs [37].”
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “Matrigel and similar products are a gelatinous mixture of proteins and growth factors secreted by Engelbreth-Holm-Swarm mouse sarcoma cells (Kleinman and Martin, 2005).”