Tumour heterogeneity and cancer cell plasticity

By Corbin E. Meacham, S. Morrison. Nature, 2013

2,309 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/25c561073cad263b2a3ad64089bb680402d6c5fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. V. Plaks
2. Zena Werb
3. Niwen Kong
4. J. Massagué
5. Aviv Regev
6. Raymond Schiffelers
7. Niko Beerenwinkel
8. Moritz Gerstung

In Cell Biology

1. Aviv Regev
2. J. Dick
3. J. Massagué
4. Niwen Kong
5. Zena Werb
6. V. Plaks
7. Antonija Krešo

In Oncology

1. Zena Werb
2. V. Plaks
3. Niwen Kong
4. J. Massagué
5. Antonija Krešo
6. E. Batlle
7. Thordur Oskarsson
8. Niko Beerenwinkel

Citations in the corpus

• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “, 2013), to estimate as accurately as possible the spectrum of cancer cells that retain the potential to contribute to tumor growth (Meacham and Morrison, 2013).”
• The MAPK pathway across different malignancies: A new perspective (2014, background): “These findings support the concept that tumors demonstrate clonal evolution and plasticity over time, adapting to microenvironment and pharmacologic exposures.(92) TABLE 2.”
• Cancer epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance (2014, background): “…there is a hierarchical arrangement for such populations versus their less tumorigenic counterparts or whether there is plasticity in which such stem-cell-like populations can always be generated, especially under stress situations, from other cells in the population (Meacham and Morrison, 2013).”
• In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior (2015, background): “The heterogeneous nature of tumors dramatically complicates the successful treatment of cancer (Meacham and Morrison, 2013).”
• EMT and tumor metastasis (2015, background): “This anomaly was recently addressed when it was demonstrated that heterogeneity in cancer does not evolve from random genetic changes but rather is orchestrated by an evolutionary conserved and organized mechanism [22].”
• Genetics and biology of prostate cancer (2018, background): “While cancer cells can exhibit different tumor-initiating capacities and self-renewal potential, the role of cancer stem cells in treatment responses remains an area of active study (Meacham and Morrison 2013).”
• Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq (2016, neutral): “Each tumor’s cellular composition, as well as the interplay between these components, may exert critical roles in cancer development (2).”
• The extracellular matrix modulates the hallmarks of cancer (2014, neutral): “These heterogeneous tumor populations are driven through very different oncogenic mutations and interact with the tumor microenvironment in different ways [131].”
• Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome (2014, background): “Intratumor heterogeneity is near ubiquitous in malignant tumors, but the extent varies between preclinical cancer models and between patients (12).”
• Metastatic Stem Cells: Sources, Niches, and Vital Pathways (2014, background): “Quantitative lineage tracing clonal analysis is needed to assess the abundance of CSCs in different tumor types (Clevers, 2011; Meacham and Morrison, 2013; Beck and Blanpain, 2013).”