Astrocytic complexity distinguishes the human brain.

By N. Oberheim, Xiaohai Wang, S. Goldman, Maiken Nedergaard. Trends in Neurosciences, 2006

741 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/25b8424e970540d6d620fbed568689a219f28305

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Developmental Neuroscience

Citations in the corpus

Glia and pain: Is chronic pain a gliopathy? (2013, background): “Basic fibroblast growth factor (bFGF or FGF-2) is induced in primary sensory neurons after nerve injury and has an active role in neuron– astrocyte signaling.”
Heterogeneity of Astrocytic Form and Function (2012, neutral): “Overall then, human astrocytes are both morphologically and functionally distinct from those of infraprimate mammals, exhibiting larger size, far greater architectural complexity and pleomorphism, and more rapid syncytial calcium signalling than their murine counterparts (8, 9, 144).”
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “It has been demonstrated that a single mature rodent astrocyte in the gray matter associates with 300–600 neuronal processes (dendrites) (Halassa et al., 2007) and contacts an estimated 20,000–120,000 synapses (up to 2,000,000 in humans) (Oberheim et al., 2006, 2009).”
Uniquely hominid features of adult human astrocytes (2009, background): “In addition to being more numerous p 0.0001) (Oberheim et al., 2006).”
Physiology of Astroglia. (2018, positive): “Morphological studies have shown that human astrocytes are much larger and more complex than mouse astrocytes (1248, 1249), and that mice transplanted with human astrocyte progenitor cells perform better in learning and memory tests (637).”
Astrocytes: a central element in neurological diseases (2016, neutral): “supported by a single astrocyte [157].”
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, neutral): “Previous studies found that human astrocytes are larger than mouse and rat astrocytes in vivo (Oberheim et al., 2006, 2009).”