Type V Protein Secretion Pathway: the Autotransporter Story

By Ian R. Henderson, F. Navarro-García, M. Desvaux, R. Fernandez, D. Ala'aldeen. Microbiology and Molecular Biology Reviews, 2004

907 citations recorded by the source corpus.

Subfields: Endocrinology, Infectious Diseases, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/25787b6df97e78c38ce05957dae705a72bbc9273

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In Infectious Diseases

In Molecular Medicine

Citations in the corpus

Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation (2013, background): “In these systems the secreted substrate and the transport functions are in the same protein (124).”
Bacterial Secretion Systems – An overview (2016, background): “In a process called two-partner secretion, a pair of proteins participates in the secretion process, in which one partner carries the β-barrel domain while the other partner serves as the secreted protein (95).”
Bacterial adhesion and entry into host cells. (2006, neutral): “…leader peptide for secretion across the inner membrane, a C-terminal domain that forms a pore in the outer membrane, and a passenger domain that is autotransported through the outer membrane pore to be exposed on the bacterial surface, for cleavage in certain cases (Henderson et al., 2004).”
Bacterial outer membrane vesicles and the host-pathogen interaction. (2005, background): “Gram-negative pathogens have developed many strategies, some specific to pathogens, to enable active virulence factors to gain access to the extracellular environment, typically the tissues or bloodstream of the host organism (Henderson et al. 2004).”
The Pangenome Structure of Escherichia coli: Comparative Genomic Analysis of E. coli Commensal and Pathogenic Isolates (2008, background): “EatA is a member of the type V autotransporter family of secretion systems, and a single peptide contains all of the functional information necessary for it to cross the inner and outer membranes of gram-negative bacteria (21).”