Bacterial outer membrane vesicles and the host-pathogen interaction.
By M. Kuehn, N. C. Kesty. Genes & Development, 2005
957 citations recorded by the source corpus.
Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.
Subfields: Endocrinology, Microbiology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/0b43187ef04130bc358e91a9c31f21dc31fa0418
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Citations in the corpus
- Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation (2016, neutral): “…outer membrane vesicles (OMVs), owing to 1108 Cell 165, 1106–1119, May 19, 2016 their size, shape, and membrane composition, interact tightly with plasma and endocytic membranes of host cells and efficiently transfer their content across these membranes (Jäger et al., 2015; Kuehn and Kesty, 2005).”
- Gram‐positive bacteria produce membrane vesicles: Proteomics‐based characterization of Staphylococcus aureus‐derived membrane vesicles (2009, background): “Because diverse Gram-negative pathogens have exploited potent virulence strategies by secreting vesicle-associated toxins, pathogenic aspects of OMVs are the major focus in this field [4].”
- Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response (2006, background): “Vesiclemediated delivery of toxins to eukaryotic cells also suggests a role for vesicles in pathogenesis (reviewed in Kuehn and Kesty, 2005).”
- Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life (2012, background): “observed microscopically over several decades (7, 40), has been proposed to 115 occur by many different mechanisms (5, 29, 42, 54, 58, 60, 96).”
- Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “, during the colonization or infection of host tissues (269, 270).”
- A revaluation of algal diseases in Korean Pyropia (Porphyra) sea farms and their economic impact (2014, background): “kr gens communicate with and intoxicate host cells (Kuehn and Kesty 2005).”
- Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles (2009, background): “Biochemical and proteomic analyses have revealed that OMV are comprised of lipopolysaccharide, phospholipids, outer membrane proteins, and soluble periplasmic proteins [ 8 ,9].”
- Origins and virulence mechanisms of uropathogenic Escherichia coli. (2008, background): “OMVs are utilized by many bacterial species to facilitate intra- and interspecies communication, the exchange of genetic material, bacterial adherence to and invasion of host cells, and the delivery of toxins (Kuehn and Kesty, 2005; Mashburn-Warren and Whiteley, 2006).”