Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

By M. Yemisci, Y. Gursoy‐Ozdemir, A. Vural, A. Can, K. Topalkara, T. Dalkara. Nature Medicine, 2009

748 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/254c231337ddd2af5009a9c1357127fa17853d7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Berislav Zlokovic
2. C. Iadecola
3. R. Bell
4. E. Winkler
5. A. Sagare
6. R. Deane
7. A. Armulik
8. G. Genové

In Neurology

1. C. Iadecola
2. Berislav Zlokovic
3. R. Bell
4. A. Sagare
5. E. Winkler
6. R. Deane
7. E. A. Newman
8. C. Betsholtz

Citations in the corpus

• Cell Biology of Ischemia/Reperfusion Injury (2012, background): “Indeed, pericytes have been shown to constrict capillaries shortly after the onset of retinal or cerebral ischemia and remain contracted when blood flow is reinstituted (Peppiatt et al., 2006; Yemisci et al., 2009).”
• Cellular and physiological mechanisms underlying blood flow regulation in the retina choroid in health disease (2012, positive): “Pericyte pathology is associated with a reduction in blood flow seen in models of retinal ischemia (Yemisci et al., 2009).”
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “…study used ex vivo cerebral slices and in vivo imaging to suggest that pericyte contraction caused by oxidative stress after brain ischemia/reperfusion leads to capillary constriction (Yemisci et al., 2009), indicating that pericytes may regulate capillary blood flow in pathological situations.”
• The immunology of stroke: from mechanisms to translation (2011, background): “Furthermore, oxidative stress leads to constriction of pericytes, contractile cells that replace myocytes in capillaries, producing more microvascular occlusion”
• Ischemia and reperfusion—from mechanism to translation (2011, background): “In a mouse model of ischemic brain injury, ischemia induces sustained contraction of pericytes on microvessels despite successful reopening of the middle cerebral arter”
• Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes (2015, neutral): “…in ischemia could stem from differences in experimental approaches (Vates et al., 2010) and from the belief that pericytes express SMA in vivo (Yemisci et al., 2009) and that SMCs are not located on brain vessels other than zero-order penetrating arterioles (Hall et al., 2014), which leads to…”
• Central nervous system pericytes in health and disease (2011, background): “Pericyte contraction has also been shown to play an essential role in obstructing capillary flow during cerebral ischemi”
• Ischemia/Reperfusion (2016, neutral): “endothelium-dependent, peroxynitrite-mediated mechanism (317, 631, 882).”
• Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging (2010, methodology): “Quantitative image analysis, including desmin-positive pericyte coverage, NG2-positive pericyte number, lectin-positive capillary length, CD31-positive capillary length, fluorescent intensity analysis of extravascular IgG and fibrin accumulation, aquaporin-4-positive or a-syntrophin-positive astrocy”
• Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury (2011, background): “…by spreading depolarization, is involved as a vasoconstrictor inducing spreading ischemia (Windmuller et al, 2005), and the vascular cells termed pericytes may contribute to capillary constrictions in normal brain tissue (Peppiatt et al, 2006) as well as in ischemic tissue (Yemisci et al, 2009).”