Tissue Cells Feel and Respond to the Stiffness of Their Substrate

By Dennis E. Discher, P. Janmey, Yu-li Wang. Science, 2005

6,325 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/244eaaa755c67087d7f06c3501d19eafa04a71ea

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In Atomic and Molecular Physics, and Optics

In Biomedical Engineering

In Cell Biology

Citations in the corpus

Modeling Physiological Events in 2D vs. 3D Cell Culture. (2017, background): “The microenvironment of cells is not only affected by microtopography but also by the stiffness of the substrate that cells adhere to, which affects bioactivities ranging from migration to differentiation (28).”
Nanotechnological strategies for engineering complex tissues (2010, background): “, mechanical properties (such as matrix stiffness, elasticity and viscosit”
A review of tissue-engineered skin bioconstructs available for skin reconstruction (2010, background): “This is important as cell attachment is likely to be influenced more at dimensions similar to those of focal adhesions than bulk dimensions, and cells are known to respond to the mechanical stiffness of their substrate (Discher et al. 2005).”
Recent advances in single-asperity nanotribology (2008, background): “In biological systems, molecular interactions at interfaces control much of the function of the system as a whole, and atomistic-level insights into the mechanical interactions are important [5, 6].”
Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “Tissue rigidity or stiffness affects many biological processe”
Modeling tissue morphogenesis and cancer in 3D. (2007, positive): “…membrane (such as encountered by mammary epithelial cells), as well as between loose matrices used by cells for migration during embryogenesis, dense connective tissue in skin, and precalcified osteoid versus rigid mature bone (Discher et al., 2005; Engler et al., 2006; Paszek et al., 2005).”
Nuclear Shape, Mechanics, and Mechanotransduction (2008, background): “At least 3 architectural motifs have been characterized in higher-order organization of interphase chromatin56,57: (1) 30-nm fibers and other configurations resulting from nucleosome packing and stacking; (2) loops of chromatin fibers ranging in size from several kilobase pairs to 10-Mbp able to int”