Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

By T. Kreisel, M. Frank, T. Licht, R. Reshef, O. Ben-Menachem-Zidon, Michael V. Baratta, S. Maier, R. Yirmiya. Molecular Psychiatry, 2014

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The chronic mild stress (CMS) model of depression: History, evaluation and usage (2016, background): “…which is probably driven by increased exposure to glucocorticoids (Walker et al., 2013): a causative role of this effect is suggested by the fact that minocycline, which blocks microglial activation, also prevents the later development of CMS-induced anhedonia (Kreisel et al., 2014).”
Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, methodology): “Similarly, another study found that a prenatal immune challenge left mice more susceptible to markedly potentiated responses to stress during their peripubertal period (Giovanoli et al. 2013).”
Depression as a microglial disease. (2015, methodology): “Microglial decline has been also found following exposure to certain regimens of chronic stress in rodents [43,49].”