Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information
By Matthew C. Good, J. Zalatan, Wendell A. Lim. Science, 2011
847 citations recorded by the source corpus.
The spatial and temporal organization of molecules within a cell is critical for coordinating the many distinct activities carried out by the cell. In an increasing number of biological signaling processes, scaffold proteins have been found to play a central role in physically assembling the relevant molecular components. Although most scaffolds use a simple tethering mechanism to increase the efficiency of interaction between individual partner molecules, these proteins can also exert complex allosteric control over their partners and are themselves the target of regulation. Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components. As a result, scaffold proteins have been exploited by evolution, pathogens, and cellular engineers to reshape cellular behavior.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/243366348a605a16721637e158c5f31c3cc75ec4
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In Molecular Biology
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Citations in the corpus
- MAP kinase pathways. (2012, background): “Cite this article as Cold Spring Harb Perspect Biol 2012;4:a011254 3 For all of the MAPK modules, specific scaffold proteins (Good et al. 2011) have been identified that dock at least two of the core kinases of the module.”
- Molecular mechanisms of long noncoding RNAs (2011, background): “Traditionally, proteins were thought to be the major players in various scaffolding complexes (Good et al., 2011).”
- An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1 (2012, positive): “Multimeric signaling complexes often engage in regulated interactions as a mechanism to control downstream signaling events (Good et al., 2011).”