Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

By B. Cool, B. Zinker, W. Chiou, L. Kifle, Ning Cao, M. Perham, R. Dickinson, A. Adler, G. Gagné, R. Iyengar and 6 more. Cell Metabolism, 2006

931 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/24203425f6892b28260ff0154f13958c708a5e49

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. D. Hardie
2. S. Hawley
3. Bruce E. Kemp
4. G. Steinberg

In Molecular Biology

1. D. Hardie
2. G. Steinberg
3. Bruce E. Kemp
4. S. Hawley
5. Fiona A. Ross
6. M. Towler
7. K. Green
8. C. Chevtzoff

In Surgery

1. D. Hardie
2. G. Steinberg
3. Bruce E. Kemp
4. S. Hawley
5. Fiona A. Ross
6. M. Towler
7. K. Green
8. C. Chevtzoff

Citations in the corpus

• Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation (2010, background): “In addition, a bewildering variety of drugs and xenobiotics has been found to activate AMPK, including (1) A-769662, developed by Abbott laboratories (Cool et al., 2006); (2) the antidiabetic biguanides, metformin (Zhou et al.”
• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase (2012, result): “The same cohort was used for all treatments, with one week separating salicylate and A-769662 injections.”
• AMPK in Health and Disease. (2009, methodology): “The mammalian AMPK domain limits were established experimentally by partial proteolysis (395), and a stable rat 1(68-163) fragment was expressed and crystallized in the presence of -cyclodextrin (an 1-4 linked heptaglucan), as had previously been performed for other starch binding domain structural ”
• The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism (2011, neutral): “, the direct small-molecule AMPK-activator A769662 (ref”
• AMPK: an emerging drug target for diabetes and the metabolic syndrome. (2009, background): “Summarized below are two examples of direct AMPK activators (Cool et al., 2006; Pang et al., 2008).”
• AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “, metformin, phenformin (a more potent sister drug to metformin), or A-769662 (a direct activator of AMPK developed by Abbot) (Cool et al. 2006)—significantly delayed tumor development (Huang et al.”