A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
By Lea Ankri, Zoé Husson, K. Pietrajtis, Rémi D Proville, C. Léna, Y. Yarom, S. Dieudonné, M. Uusisaari. 2015
51 citations recorded by the source corpus.
The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells. DOI: http://dx.doi.org/10.7554/eLife.06262.001
Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Neurology
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- Jinsook Kim
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Citations in the corpus
- Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “Recent studies have also discovered evidence of long-range sparse feedback projections from deep cerebellar nuclei to the cerebellar input layer (Houck and Person 2014; Ankri et al., 2015; Houck and Person 2015; Gao et al., 2016; Low et al., 2018).”
- Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus. (2018, background): “However, with the exceptions of a subclass of NC neurons (Ankri et al., 2015; Gao et al., 2016) and neurons that project to the vestibular nuclei (Bagnall et al.”
- Computational Principles of Supervised Learning in the Cerebellum (2018, unknown): “This recurrent path can be configured as either a positive or a negative feedback loop, with excitatory neurons in the cerebellar nuclei targeting both excitatory and inhibitory cells in the granule cell layer (Houck & Person 2015) and inhibitory neurons in the cerebellar nuclei targeting inhibitory”