Innate immune activation in neurodegenerative disease

By Michael T. Heneka, Markus P Kummer, E. Latz. Nature reviews. Immunology, 2014

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Depression as a microglial disease. (2015, background): “Microglial activation and associated neuroinflammation evolved as an adaptive process, allowing the elimination of pathogenic challenges; however, under many circumstances, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, activated microglia become neurotoxic and da”
Inflammasomes in neuroinflammatory and neurodegenerative diseases (2019, background): “Hence, increased levels of IL-1b and IL-18 are often observed upon CNS infection, brain injury, and neurodegenerative diseases (Heneka et al, 2014, 2018).”
Role of neuroinflammation in neurodegeneration development (2023, background): “This binding activates the surrounding microglia, which release numerous cytokines and chemokines and recruit more glial cells to the Aβ locus.(32) Activated microglia and astrocytes can phagocytize Aβ through multiple receptors to protect neurons,(33,34) but failure to clear the aggregates leads to”