Aging and survival: the genetics of life span extension by dietary restriction.

By William B. Mair, A. Dillin. Annual Review of Biochemistry, 2008

630 citations recorded by the source corpus.

Subfields: Aging, Physiology

View Paper: https://www.semanticscholar.org/paper/23ca7917be251aad66989dca37fd5a04188746d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. V. Longo
2. Linda Partridge
3. Brian K. Kennedy
4. P. Cohen
5. Catherine Au
6. F. Cabreiro
7. D. Gems
8. Luigi Fontana

In Physiology

1. V. Longo
2. Linda Partridge
3. Brian K. Kennedy
4. Catherine Au
5. I. Scharf
6. F. Cabreiro
7. D. Gems
8. Luigi Fontana

Citations in the corpus

• Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism (2013, background): “…28, 2013 ª2013 Elsevier Inc. formin recapitulates the effects of dietary restriction (DR), the controlled reduction of food intake that can improve late-life health and increases lifespan in organisms ranging from nematodes and fruit flies to rodents and rhesus monkeys (Mair and Dillin, 2008).”
• Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “Rapamycin Extends Life Span beyond the Maximum Achieved by Dietary Restriction The TOR pathway may play an important role in DR, because the effects of DR are abrogated in TOR pathway mutant yeast, worms, and flies (Bishop and Guarente, 2007; Mair and Dillin, 2008).”
• A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “Dietary restriction (DR) promotes metabolic and cellular changes that affect oxidative damage and inflammation, optimize energy metabolism, and enhance cellular protection (Haigis and Yankner, 2010; Johnson et al., 2000; Lee et al., 2012b; Longo and Finch, 2003; Mair and Dillin, 2008; Narasimhan et ”
• Dietary protein mediates a trade-off between larval survival and the development of male secondary sexual traits (2013, background): “It has been known for nearly a century that moderate restriction of dietary nutrients (dietary restriction) results in extended longevity and reduced reproduction in a broad range of animal species (Mair & Dillin 2008; Fontana, Partridge & Longo 2010; Nakagawa et al. 2012).”
• With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, neutral): “The mammalian orthologs of PHA-4, the Foxa transcription factors Foxa1, Foxa2, and Foxa3, also play important roles during development, and act later in life to regulate glucagon production and glucose homeostasis in response to fasting (Mair and Dillin, 2008).”
• The evolution of Fox genes and their role in development and disease (2009, background): “Severe reductions in food intake increase lifespan in some species, including nematode”
• Late bloomers and baby boomers: ecological drivers of longevity in squamates and the tuatara (2015, background): “The latter is a well-known factor, extending longevity in various organisms (e.g. Mair & Dillin, 2008).”
• Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, neutral): “A wide range of interventions has been used to impose DR, even within single species, and the mechanisms through which they extend lifespan can differ (Bass et al., 2007; Cypser et al., 2013; Mair and Dillin, 2008; Tatar et al., 2014).”