Identification of a Primary Target of Thalidomide Teratogenicity

By Takumi Ito, H. Ando, Takayuki Suzuki, T. Ogura, K. Hotta, Yoshimasa Imamura, Y. Yamaguchi, H. Handa. Science, 2010

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Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS (2015, background): “b, Immunoblot of CK1α protein levels in the bone marrow (1,2) and peripheral blood (3,4) mononuclear cells of AML patients treated with lenalidomide as part of a clinical trial.”
Thalidomide‐induced teratogenesis: History and mechanisms (2015, background): “Several studies have demonstrated that Fgf8 signaling is reduced or lost in developing chicken and rabbit limbs, and zebrafish fins following thalidomide exposure (Hansen et al., 2002; Ito et al., 2010; Knobloch et al., 2011).”
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15 (2017, background): “In another example of how chemical structure can influence neosubstrate preference, CC-885 was identified in a screen of IMiD derivatives as catalyzing the recruitment of GSPT1, a translation termination factor essential for myeloid leukemia cell proliferation, to CUL4-CRBN (44).”