Thalidomide‐induced teratogenesis: History and mechanisms
By N. Vargesson. Birth Defects Research Part C Embryo Today Reviews, 2015
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Nearly 60 years ago thalidomide was prescribed to treat morning sickness in pregnant women. What followed was the biggest man‐made medical disaster ever, where over 10,000 children were born with a range of severe and debilitating malformations. Despite this, the drug is now used successfully to treat a range of adult conditions, including multiple myeloma and complications of leprosy. Tragically, a new generation of thalidomide damaged children has been identified in Brazil. Yet, how thalidomide caused its devastating effects in the forming embryo remains unclear. However, studies in the past few years have greatly enhanced our understanding of the molecular mechanisms the drug. This review will look at the history of the drug, and the range and type of damage the drug caused, and outline the mechanisms of action the drug uses including recent molecular advances and new findings. Some of the remaining challenges facing thalidomide biologists are also discussed. Birth Defects Research (Part C) 105:140–156, 2015. © 2015 The Authors Birth Defects Research Part C: Embryo Today: Reviews Published by Wiley Periodicals, Inc.
Subfields: Genetics, Hematology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f28aeb8f89a06a3550b05f7af286d00ae9860420
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Citations in the corpus
- Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, methodology): “Thalidomide (Thalomid) was synthesized by the CIBA pharmaceutical company in 1954 and was initially used for mitigating morning sickness as a nonaddictive and non-barbiturate tranquilizer (Table 1).(398) However, it was withdrawn by FDA due to serious teratogenic events (fundamentally attributed to ”
- A Review of SARS-CoV-2 and the Ongoing Clinical Trials (2020, methodology): “Through decreasing the synthesis of TNF-alpha, thalidomide has been used as a treatment for multiple inflammatory diseases, such as Crohns disease and Behcets disease [80].”
- Machine learning applications in drug development (2019, background): “One of these forms can treat morning sickness; the other form can have teratogen effects [91].”