Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

By Irene Noguera-Troise, C. Daly, N. Papadopoulos, Sandra Coetzee, P. Boland, N. Gale, H. Lin, G. Yancopoulos, Gavin Thurston. Nature, 2006

1,009 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/226ed9325b992c8787d3e31f9a8755679d897ae2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Alicia S. Chung
2. N. Ferrara
3. John Lee
4. M. Ilagan
5. Ali Khademhosseini
6. P. Wen
7. Raphael Kopan
8. J. Rouwkema

In Cell Biology

1. Ali Khademhosseini
2. A. Capobianco
3. Kelly L. Weaver
4. Prathibha Ranganathan

In Molecular Biology

1. Alicia S. Chung
2. N. Ferrara
3. Ali Khademhosseini
4. J. Rouwkema
5. John Lee
6. M. Ilagan
7. P. Wen
8. A. Capobianco

Citations in the corpus

• Exciting New Advances in Neuro-Oncology (2010, background): “59 Finally, tumor cells secrete chemokines that serve to recruit proangiogenic myeloid cells to the tumor.”
• The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. (2009, neutral): “, 2007; Siekmann and Lawson, 2007), or in experimental tumors (Li et al., 2007; Noguera-Troise et al., 2006; Ridgway et al., 2006).”
• The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism (2009, background): “Notch signaling has emerged as a specific therapeutic target for T cell acute lymphoblastic leukemia (Weng et al., 2004) and colon cancer (van Es et al., 2005), as well as a potential target in the effort to curb tumor angiogenesis (Noguera-Troise et al., 2006; Ridgway et al., 2006).”
• Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks. (2016, background): “Studies that stimulate vascular maturation and stabilization by contrast result in reduced vascular branching and density, but enhanced vessel diameter and perfusion [80].”
• Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “The role of DLL4–Notch signalling during physiological angiogenesis is to limit excessive angiogenesis as a negative feedback mechanism and to promote the formation of a functional, mature vasculatur”
• Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “Recently, antibodies that are selective for the Notch ligand Delta-like 4 ( DLL4 ) were shown to inhibit tumour growth by deregulating angiogenesis without much of the toxicity related to γ-secretase inhibition in animal model”