Pathology: Cancer cells compress intratumour vessels

By T. Padera, Brian R. Stoll, Jessica B. Tooredman, Diane E. Capen, E. Tomaso, Rakesh K. Jain. Nature, 2004

856 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/225cf29c3622bff7d14746680ab1d1c67bc0b7d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Molecular Biology

In Oncology

Citations in the corpus

ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, positive): “…blood perfusion and hypoxia in tumors results not only from the abnormal structure and leakiness of tumor vessels, but also from the compression of vessels by extravascular components in tumors (Chauhan et al., 2013, 2014; Jain, 1988, 2014; Padera et al., 2004; Stylianopoulos et al., 2012).”
High interstitial fluid pressure — an obstacle in cancer therapy (2004, background): “Furthermore, the growing tumour cells might compress the vessels, and so further reduce flo”
Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “Hence, to improve such situations, encapsulating these small molecules in nanosized drug carriers is routinely carried out to enhance their pharmacokinetics, provide tumor selectivity and reduce side effects [34].”
Nanomedicine therapeutic approaches to overcome cancer drug resistance (2013, background): “These areas result from abnormal angiogenesis or from the compression/closing of blood vessels by cancer cells [70].”
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors (2012, background): “Moreover, the magnitude of the calculated compressive stress—comparable with the magnitude measured in spheroids (31, 32)—was large enough to compress vessels and nearby organs, obstruct large blood vessels with life-threatening consequences, or induce pain by pressing on nerves (18).”
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging (2009, background): “Diphtheria toxin accumulates in human cells, halting protein synthesis and eventually inducing apoptosis, but does not affect murine cell”
Delivering nanomedicine to solid tumors (2010, background): “Finally, proliferating tumor cells and/or stromal cells exert solid stress and compress blood vessels, which might cause vessel collapse”
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “Other possible factors that may contribute to the high Pif are the lack of functioning lymphatics in central tumor areas (262, 350), intratumoral blood vessel compression due to solid stress from the growing tumor (351), and direct effects of growth factors like PDGF, TGF- , and VEGF (187).”
Angiogenesis in Cancer (2006, positive): “In addition, the pressure generated by proliferating cancer cells compresses intratumoral blood and lymphatic vessels and leads to an abnormal microenvironment characterized by an impaired blood supply, interstitial hypertension, hypoxia, and acidosis (Padera et al 2004).”
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. (2007, background): “The lack of functional lymphatics in tumors contributes to the elevated IFP and probably results from compression of these vessels by proliferating cancer cells (11) and/ or impaired lymphatic valves (12).”