A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
By Shicheng Su, Qiang Liu, Jingqi Chen, Jianing Chen, Fei Chen, Chonghua He, Di Huang, Wei Wu, Ling Lin, Wei Huang and 7 more. Cancer Cell, 2014
696 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/224c9058268be71238514defd7892a97d7a8c2e1
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Citations in the corpus
- Tumor-associated macrophages: from mechanisms to therapy (2014, background): “Some factors such as GM-CSF act in protumoral or antitumoral fashion dependent on context (Pyonteck et al., 2013; Su et al., 2014).”
- Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis (2019, result): “Our results were in accordance with previous study, which comprehensively demonstrated that CCL18 TAMs infiltration in the tumor invasive front might establish an aggressive TME and could regulate breast cancer cells an EMT shift to increase metastatic ability [33].”
- CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. (2018, background): “…of cytokines, such as CCL18 and IL-1b, in the tumor microenvironment may be responsible for initiating the NF-kB signaling by activating IKK in the CAF subset (Erez et al., 2010; Su et al., 2014), IKK activation is usually not sustainable due to numerous negative feedback loops (Perkins, 2012).”
- Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015, unknown): “Exposure of macrophages to IL-4 produced by CD4+ T cells and/or cancer cells (59, 63), growth factors such as colony stimulating factor-1 (CSF1) (64), GM-CSF (65), and TGFβ secreted by cancer cells, can also induce the M2 switch.”
- Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions (2015, result): “In line with recently reported findings in macrophages [17], our data show that inhibition of CD8 T cell motility by lactic acid cannot be simply ascribed to its effect on the acidification of the culture media; rather simultaneous availability of lactate and H is necessary to regulate the motility ”
- Tumor-associated macrophages: from basic research to clinical application (2017, background): “In human breast cancer models, binding of CCL18 to its receptor PITPNM3 mediated the recruitment of macrophages in collaboration with CSF2 [11].”
- Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression (2015, background): “, 2012), while CCL18 and Ephrin is presented by monocytes and macrophages (Lu et al., 2014; Su et al., 2014), and TGF-β is released from myofibroblasts and platelets (Labelle et al.”