Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

By M. Guilliams, Florent Ginhoux, Claudia V. Jakubzick, Shalin H. Naik, N. Onai, Barbara U. Schraml, É. Segura, R. Tussiwand, S. Yona. Nature reviews. Immunology, 2014

1,681 citations recorded by the source corpus.

The mononuclear phagocyte system (MPS) has historically been categorized into monocytes, dendritic cells and macrophages on the basis of functional and phenotypical characteristics. However, considering that these characteristics are often overlapping, the distinction between and classification of these cell types has been challenging. In this Opinion article, we propose a unified nomenclature for the MPS. We suggest that these cells can be classified primarily by their ontogeny and secondarily by their location, function and phenotype. We believe that this system permits a more robust classification during both steady-state and inflammatory conditions, with the benefit of spanning different tissues and across species.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/222c941fccaf13802be48b9c9ce2fff55622b2c1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. (2016, background): “In contrast, DCs are starry cells that present antigens on major histocompatibility complex molecules and activate naive T lymphocytes.(3) Human DCs are classified into 2 main groups: plasmacytoid and myeloid (mDC).”
The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis (2017, background): “These technical developments revealed several facts: (1) almost all microglia in the central nervous system are derived from the embryonic yolk sac and are maintained throughout life; (2) in the intestinal tract, macrophages derived from the embryonic yolk sac are replaced with macrophages from bone”
Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, background): “…macrophages, newborn monocyte-derived macrophages, and adult monocyte-derived macrophages function alongside one another, and in inflamed tissues adult monocyte-derived cells with features of macrophages and dendritic cells (Guilliams et al., 2014) are added to the already-diverse population.”
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes and progenitors (2017, background): “, spectrum of states for AS DCs)—thus addressing limitations in the existing classification that relies on a small number of markers (39).”
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control (2018, background): “cDCs can be divided into at least two subsets, conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) (Guilliams et al., 2014; Merad et al., 2013).”
Macrophage plasticity, polarization, and function in health and disease (2018, background): “…observed that embryonic and adultderived macrophages co-exist in many different organs (Davies et al., 2013; Divangahi et al., 2015; Galli, Borregaard, & Wynn, 2011; Guilliams et al., 2014; Saijo & Glass, 2011; Sheng, Ruedl, & Karjalainen, 2015; Stefater et al., 2011; Varol, Mildner, & Jung, 2015).”
Immune responses to stroke: mechanisms, modulation, and therapeutic potential. (2020, background): “DCs are antigen-presenting cells with high migratory capacity, derived from dendritic (conventional cDC1 and cDC2 and plasmacytoid DC) or monocytic (moDC) lineages (83).”