Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor.

By E. Gravallese, Cathy Manning, A. Tsay, Akifumi Naito, C. Pan, E. Amento, S. Goldring. Arthritis & Rheumatism, 2000

739 citations recorded by the source corpus.

Subfields: Molecular Biology, Orthopedics and Sports Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/2215230f61d5a05146cb5ea9bb490ae471d62d95

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Georg Schett
2. I. McInnes
3. C. Benoist

In Rheumatology

1. I. McInnes
2. Georg Schett
3. S. Goldring
4. S. Gaffen
5. Gary S. Firestein

Citations in the corpus

• Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. (2008, neutral): “These findings notwithstanding, there is still significant interest in the potential immunomodulatory effects of RANKL and RANKL inhibition.”
• Cytokines in the pathogenesis of rheumatoid arthritis (2007, background): “In rheumatoid arthritis, osteoclasts at the interface between synovial tissue and articular bone induce bone resorption, which in turn permits invasion by cells of the synovial membrane and results in pannus formatio”
• Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology (2001, neutral): “effect is prevented by OPG treatment [111, 112, 113].”
• Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis (2003, neutral): “Primer sequences were RANKL sense, 5′CTATTTCAGAGCGCAGATGGAT-3′; RANKL antisense, 5′-TATGAGAACTTGGGATTTTGATGC-3′ (26); RANK sense, 5′-TTAAGCCAGTGCTTCACGGG-3′; RANK antisense, 5′-ACGTAGACCACGATGATGTCGC-3′ (27); OPG sense, 5′-GCTAACCTCACCTTCGAG-3′; OPG antisense, 5′-TGATTGGACCTGGTTACC-3′ (28); GAPDH se”
• TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. (2001, background): “A role for TRANCE/RANKL in bone resorption in RA is suggested by the identification of TRANCE/RANKL mRNA(3,29) and protein(29) in cultured synovial fibroblasts from patients with RA and in CD4 and CD8 T lymphocytes in RA synovial tissues.(3,30,31) Additional evidence that TRANCE/RANKL plays a critic”