The anatomical and cellular basis of immune surveillance in the central nervous system

By R. Ransohoff, B. Engelhardt. Nature reviews. Immunology, 2012

905 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Astrocyte crosstalk in CNS inflammation (2020, background): “The CNS parenchyma is usually considered an ‘immune privileged’ compartment under healthy conditions, which provides limited access to peripheral antibodies and leukocytes (Louveau et al., 2015a; Ransohoff and Engelhardt, 2012).”
The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “Various hypotheses have been proposed to explain how peripheral immune cells may cross the BBB under pathological conditions (for review, see Ousman and Kubes, 2012; Ransohoff and Engelhardt, 2012).”
The blood-brain barrier in Alzheimer's disease (2017, neutral): “The β 2 integrins are mainly involved in neutrophil extravasation across the in ﬂ amed BBB, whereas VLA-4 mainly contributes to T cell traf ﬁ cking in the CNS (Ransohoff and Engelhardt, 2012; Gorina et al., 2014; Zenaro et al., 2015).”
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity (2014, neutral): “[53] R.”
Blood–brain barrier structure and function and the challenges for CNS drug delivery (2013, background): “especially vessels on the meningeal pial surface of the brain, and post-capillary venules (Ransohoff and Engelhardt 2012).”