Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.

Proceedings of the National Academy of Sciences of the United States of America, 2005

634 citations recorded by the source corpus.

Citations in the corpus

Development of a BACarray translational profiling approach for the molecular characterization of CNS cell types (2008, positive): “…this upregulation may serve as an adaptive response to enhanced excitatory glutamatergic signaling in striatonigral neurons associated with the activation of D1 dopamine receptors by cocaine administration (Flores-Hernandez et al., 2002; Lee et al., 2006; Valjent et al., 2005; Wolf et al., 2004).”
Regulation of NMDA receptor trafficking by amyloid-β (2005, neutral): “PP2B may act directly on STEP as a substrate or through PP1 and inhibitor-1 or DARPP-32 (ref”
Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol (2008, positive): “These results extend previous immunofluorescence studies that identified MSN populations in which ERK was activated using dynorphin, enkephalin, or D1R immunoreactivities (Zhang et al., 2004; Valjent et al., 2005).”
The Physiology, Signaling, and Pharmacology of Dopamine Receptors (2011, positive): “This suggests that the inhibition of excitatory glutamate receptors by GSK-3 in response to dopamine in MSNs expressing D2 dopamine receptors could stimulate locomotion.”