Gene expression pattern Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain

By G. Stump, Anne-Laurence Klein, Ueli Suter, V. Taylor. 2002

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For the long run: maintaining germinal niches in the adult brain. (2004, background): “The finding that SVZ and SGZ blasts and macrophages (Mercier et al., 2002).”
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, result): “This idea is supported by the observations that the Notch targets Hes1 and Hes5 are expressed in adult neurogenic niches (Stump et al., 2002; Crews et al., 2008) and that stem cells in the adult hippocampus (Fig.”
Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide (2003, background): “Interestingly, in early postnatal development Hes5 RNA is expressed in a subpopulation of cells of the hippocampal dentate gyrus and subventricular zone and in the cortex (Stump et al., 2002).”
Notch signaling in the mammalian central nervous system: insights from mouse mutants (2005, background): “A gene expression study found that Notch pathway components are expressed in the early postnatal and adult mouse brain, both in germinal zones and in neuron”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “This raises the possibility that Notch is also involved in stem cell/ progenitor maintenance in adult neurogenic niches, where Notch1 and Jagged1 are expressed (Stump et al. 2002; Irvin et al. 2004; Nyfeler et al. 2005).”