The role of STATs in transcriptional control and their impact on cellular function

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Stat proteins and oncogenesis. (2002, background): “Since that time a large number of growth factor receptors and some nonreceptor tyrosine kinases have been found to lead to the activation of these transcription factors (2).”
IL-6 in inflammation, autoimmunity and cancer (2020, background): “Activated JAK phos-phorylates tyrosine residues in the cytoplasmic domain of gp130 (30, 31, 61, 62, 102, 103).”
STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “The STATs have an SH2 domain through which they make contact with the receptor, dimerize and move into the nucleus (Bromberg and Darnell, 2000) (Fig.”
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. (2002, background): “specific promoter sequences and induce gene expression (2, 6).”
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells (2001, background): “Moreover, constitutively-activated STAT mutants have been shown to alter cellular growth control and directly induce cellular transformation (Ariyoshi et al., 2000; Bromberg et al., 1999; Bromberg and Darnell, 2000; Demoulin et al., 2000).”