Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

By R. Garcia, Tammy L. Bowman, G. Niu, Hua Yu, S. Minton, C. Muro-Cacho, C. Cox, R. Falcone, Rita Fairclough, S. Parsons and 5 more. Oncogene, 2001

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis (2002, background): “EGFR and Src signaling pathways, both of which can induce VEGF expression (Ellis et al., 1998; Mukhopadhyay et al., 1995a; Petit et al., 1997; Wiener et al., 1999), are known to contribute to Stat3 activation in breast cancers (Garcia et al., 1997, 2001).”
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. (2002, background): “activation and survival of human myeloma cells, breast cancer cells, and prostate cancer cells (30, 31).”
STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “STAT3 negative dominant expression in these cells brings about cell growth arrest and apoptosis (Garcia et al., 2001).”
Src family kinases in tumor progression and metastasis (2003, background): “In human breast cancer cell lines expressing elevated EGFR and c-Src kinase activities, Stat3 is constitutively activated in a SFK and JAKdependent fashion [106].”