Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

By E. Zamir, M. Katz, Yehudit Posen, N. Erez, Kenneth M. Yamada, B. Katz, Shin Lin, D. C. Lin, A. Bershadsky, Zvi Kam and 1 more. Nature Cell Biology, 2000

618 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/20a24362e6cf2774ad060a6e7687fe0e76cb2182

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Citations in the corpus

Adhesion-dependent cell mechanosensitivity. (2003, background): “An extreme consequence of changes in mutual position of focal adhesion components is their sorting, i.e., when myosindriven force specifically extracts molecular complexes containingα5β1 integrin and tensin from focal adhesions (Pankov et al. 2000, Zamir et al. 2000).”
Regulation of actin assembly associated with protrusion and adhesion in cell migration. (2008, background): “The elongation of fibrillar adhesions depends on the deformability of the extracellular matrix (264).”
Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. (2002, background): “Fibrillar adhesions have been shown to contain fibronectin, α5β1 integrin, and tensin (Katz et al., 2000; Zamir et al., 2000).”
Integrin-mediated mechanotransduction (2016, background): “…of the effects of ECM stiffness on cell proliferation and differentiation can be attributed to YAP and TAZ (YAP/ TAZ), two transcriptional activators that operate in the Hippo pathway to induce the expression of prosurvival genes (Dupont et al., 2011; Aragona et al., 2013; Zanconato et al., 2015).”
Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement (2000, background): “It is now clear that sites of ECMintegrin adhesion are in fact, dynamic, often heterogeneous structures, varying in size and organization (Zamir et al., 1999, 2000).”
Phagocytosis and the actin cytoskeleton. (2001, background): “The focal adhesion is a complex assembly of cytoskeletal and signalling proteins, and indeed the term ‘focal adhesion’ may, in fact, encompass a variety of distinct structures, whose components change over time (Zamir et al., 2000).”
The relationship between force and focal complex development (2002, background): “In addition to containing more molecular components than focal complexes, focal adhesions require much more time ( 60 min) to become fully established (Zamir et al., 2000).”
Rac and Rho GTPases in cancer cell motility control (2010, background): “All these proteins can bind adaptor proteins through SH2, SH3 or proline rich domains to recruit actin binding proteins (vinculin, paxillin and a-actinin) as well as regulatory molecules PI3K to focal complexes [39,40].”
Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts (2001, background): “These focal adhesions may also be mobile under some conditions (Davies et al., 1994; Smilenov et al., 1999; Zamir et al., 2000).”