Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

By J. Parsons, K. Martin, J. K. Slack, Joan M. Taylor, Scott A. Weed. Oncogene, 2000

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Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression (2002, neutral): “In these mice, the trun- cordingly, inhibition of FAK reduces cell motility (recated receptor exerts a dominant-negative effect on viewed in Parsons et al, 2000).”
Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. (2002, background): “Integrin ligation leads to clustering of integrins into focal contacts, areas of the cell that are in close apposition to the substrate (Izzard and Lochner, 1980; Chen and Singer, 1982), and that are rich in signaling and cytoskeletal proteins, including FAK, paxillin, and vinculin (Singer, 1982; Pa”
Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. (2002, background): “Tyrosine phosphorylation and activation of FAK accompanies integrin-mediated adhesion, and dephosphorylation promptly occurs when cells are detached (7, 46, 47).”