Idiosyncratic drug hepatotoxicity

By N. Kaplowitz. Nature reviews. Drug discovery, 2005

1,015 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/202fd3003bfdc120b0cc275ba28c201be45b86dd

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In Pharmacology

Ali Khademhosseini

Citations in the corpus

Organ-on-a-Chip Platforms for Studying Drug Delivery Systems (2014, background): “Drug hepatotoxicity is one of the main concerns in identifying new drugs [85], thus studying hepatoxicity of nanoparticles is very important for developing novel drug delivery platforms.”
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies (2007, background): “17; Kaplowitz, 2005).”
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening (2006, background): “variable latency period, and are usually considered to be idiosyncratic (Kaplowitz 2005).”
EASL Clinical Practice Guidelines: management of cholestatic liver diseases. (2009, background): “Both environmental and genetic factors may determine susceptibility [180].”
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. (2021, background): “In addition, characterizing the injury by latency, pattern of injury (e.g., R -value), mortality risk (Hy ’ s law) (23,24), and outcome 14.”
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting (2016, background): “T liver plays a critical role in the synthesis of important proteins and the metabolism of xenobiotic; the failure of these functions is closely related to disease development and drug-induced toxicity (1).”