Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression…

By É. Pasmant, I. Laurendeau, D. Heron, M. Vidaud, D. Vidaud, I. Bièche. Cancer Research, 2007

656 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/20199d5626872b4397f3c7182bf36a9f0f32e98c

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Citations in the corpus

Mechanisms of long noncoding RNA function in development and disease (2016, background): “When lncRNAs in plasma from myocardial infarction patients were profiled, a mitochondrial lncRNA named long intergenic noncoding RNA predicting cardiac remodeling (LIPCAR) was found to significantly correlate with mortality caused by CVD and could thus be considered as a biomarker [173].”
A review on coronary artery disease, its risk factors, and therapeutics (2019, background): “Tissues that are affected by atherosclerosis contains a noncoding, antisense RNA of unknown function, named antisense noncoding RNA in the INK4 locus (ANRIL), also known as CDKN2B‐AS (Pasmant et al., 2007).”
Non‐coding RNAs: regulators of disease (2010, background): “It is not surprising, then, that the dysregulation of lncRNAs appears to be a primary feature of many complex human diseases, including leukaemia [175], colon cancer [176], prostate cancer [177], breast cancer [178], hepatocellular carcinoma [175,179], psoriasis [180], ischaemic heart disease [181,1”
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene (2010, neutral): “ANRIL contains 19 exons, a polyadenylation site in the last exon and spans over 126 kb of genomic sequence that is deleted in the melanoma–neural system tumor syndrome family analyzed by previous study (Pasmant et al., 2007).”
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (2010, methodology): “ANRIL was first uncovered in a genetic analysis of familial melanoma patients with neural system tumors [27].”
The Genetic Signatures of Noncoding RNAs (2009, neutral): “splicing patterns in various cancers [47,106,158,161,186,187], and”
lncRNAdb: a reference database for long noncoding RNAs (2010, background): “It also aims to decrease instances of replication and unknown identity by the inclusion of aliases such as p15AS , which was reported as a novel antisense RNA (24), but appears to be an unspliced isoform of a previously described ncRNA called ANRIL (25), and Gomafu (26), which is also known as MIAT ”
Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a (2010, neutral): “…and Pol II with RNA ChIP (Figure 1E), we detected that the ANRIL transcript initiates at start sites upstream of the INK4a and ARF genes on the opposing strand, preceding previously reported start sites by several hundred bases (Pasmant et al., 2007; Sharpless and DePinho, 2007; Yu et al., 2008).”