A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.

By Xinzhong Dong, S. Han, M. Zylka, M. Simon, David J. Anderson. Cell, 2001

685 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/1ff2baa0ed5d0ef0b80bd5a6a410995bf4c29616

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. David E. Gloriam
2. Helgi B. Schiöth
3. Robert Fredriksson
4. David J. Anderson

In Molecular Biology

1. David E. Gloriam
2. Helgi B. Schiöth
3. Robert Fredriksson
4. David J. Anderson

In Sensory Systems

1. David E. Gloriam
2. David J. Anderson
3. Helgi B. Schiöth
4. Robert Fredriksson

Citations in the corpus

• The G protein-coupled receptor subset of the rat genome (2007, background): “The group of MRGs are located primarily in sensory neurons of the dorsal root ganglion and are implicated in perception of pain [23].”
• Comparative Hi-C Reveals that CTCF Underlies Evolution of Chromosomal Domain Architecture (2015, neutral): “A similar rearrangement event occurred at the Mrgpr gene cluster in the mouse genome (Dong et al., 2001), again preserving the structure of the neighboring domains (Figure S7).”
• Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. (2009, positive): “Mice lacking a cluster of Mrgpr genes display significant deficits in itch induced by”
• Cellular and Molecular Mechanisms of Pain (2009, neutral): “A large percentage of the c-Ret-positive population also binds the IB4 isolectin and expresses G protein-coupled receptors of the Mrg family (Dong et al., 2001), as well as specific puri- 268 Cell 139, October 16, 2009 ©2009 Elsevier Inc. nergic receptor subtypes, notably P2X3.”