Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension
By Changjin Lee, Sally Vitali. Circulation, 2012
744 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/1fec8fc86ff75d875eccf9b3008526a68db83066
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In Cardiology and Cardiovascular Medicine
In Molecular Biology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “MSCs-derived exosomes directly suppressed early pulmonary inflammation and vascular remodeling [70] through the suppression of hyper-proliferative pathways, including signal transducer and activator of transcription 3 (STAT3)-mediated signaling.”
- Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “(25) demonstrated that exosomes mediate the cytoprotective effect of bone marrow MSCs in hypoxia-induced PH.”
- Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Bone marrow MSC-derived exosomes protect against various types of disease conditions, including myocardial ischemia/reperfusion injury [82], hypoxia-induced pulmonary hypertension [261], and brain injury [272].”
- MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity. (2018, background): “Although the use of MSCs for tissue repair such as cartilage repair was first predicated on the hypothesis that these cells could differentiate into chondrocytes to replace the damaged tissue, it is now widely accepted that MSCs secrete factors to promote tissue repair [9e11].”
- Mechanisms of mesenchymal stem/stromal cell function (2016, background): “Exosomes purified from MSCs have garnered tremendous interest in the field of regenerative medicine based on their ability to reduce apoptosis/necrosis in rodents after ischemic injury to the heart [158, 159], brain [160, 161], lung [162], liver [163], or kidney [164].”
- Manufacturing Exosomes: A Promising Therapeutic Platform. (2018, positive): “Indeed, postinjury tissue regeneration studies have revealed that the regenerative effect of exosomes can be as potent as that of parent cells in promoting regeneration and functional recovery in experimental animal models, including stroke [14], traumatic brain injury [15], pulmonary hypertension [”
- Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. (2015, neutral): “Improve lung vascular remodelling (90) 1.”