Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications.
By S. Rani, A. Ryan, M. Griffin, T. Ritter. Molecular Therapy, 2015
1,048 citations recorded by the source corpus.
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the current interest in therapeutic application of MSCs to various disease settings can be linked to their immunosuppressive and anti-inflammatory properties. One of the key mechanisms of MSC anti-inflammatory effects is the secretion of soluble factors with paracrine actions. Recently it has emerged that the paracrine functions of MSCs could, at least in part, be mediated by extracellular vesicles (EVs). EVs are predominantly released from the endosomal compartment and contain a cargo that includes miRNA, mRNA, and proteins from their cells of origin. Recent animal model-based studies suggest that EVs have significant potential as a novel alternative to whole cell therapies. Compared to their parent cells, EVs may have a superior safety profile and can be safely stored without losing function. In this article, we review current knowledge related to the potential use of MSC-derived EVs in various diseases and discuss the promising future for EVs as an alternative, cell-free therapy.
Subfields: Cancer Research, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b25f7922b600dc2146496e9f047efc29a45cc3f1
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In Cancer Research
In Molecular Biology
Citations in the corpus
- Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “Thus, low molecular antioxidant, curcumin [89,90], anticancer agents, Doxorubicin (Dox) [92,93] and Paclitaxel (PTX) [94], and a model drug Rhoda-mine 123 [94] were loaded into exosomes or exosome-like vesicles by incubation at room temperature (RT).”
- Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine (2018, background): “vesicles secreted by MSCs as a possible non-cellular therapy [3].”