Chaperone-mediated autophagy: a unique way to enter the lysosome world

By Susmita Kaushik, A. Cuervo. Trends in Cell Biology, 2012

826 citations recorded by the source corpus.

All cellular proteins undergo continuous synthesis and degradation. This permanent renewal is necessary to maintain a functional proteome and to allow for rapid changes in levels of specific proteins with regulatory purposes. Although for a long time lysosomes were considered unable to contribute to the selective degradation of individual proteins, the discovery of chaperone-mediated autophagy (CMA) changed this notion. Here, we review the characteristics that set CMA apart from other types of lysosomal degradation and the subset of molecules that confer cells the capability to identify individual cytosolic proteins and direct them across the lysosomal membrane for degradation.

Subfields: Cell Biology, Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/1fe931b5f7c1c2ed6e54c5909a5e906d6d394db8

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In Cell Biology

1. R. Yadav
2. H. Chae
3. Andrea Ballabio
4. Hyung-Ryong Kim
5. H. Rashid

In Epidemiology

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In Parasitology

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Citations in the corpus

• The lysosome: from waste bag to potential therapeutic target. (2013, background): “Chaperone-mediated autophagy is a process by which cytosolic proteins harboring specific recognition motifs are delivered to the lysosomes via the action of a chaperone and the lysosomal receptor LAMP-2A (Dice, 1990; Cuervo and Dice, 1996; Kaushik and Cuervo, 2012).”
• Triglyceride metabolism in the liver (2017, neutral): “In chaperone-mediated autophagy (CMA), lysosomal degradation of specific proteins is regulated upon recognition by CMA receptors (133).”
• Signals for the lysosome: a control center for cellular clearance and energy metabolism (2013, background): “In this way, TFEB controls the starvation response by activating both lipophagy (5) and fatty acid β-oxidation (6).”
• Molecular definitions of autophagy and related processes (2017, neutral): “CMA involves the direct delivery of cytosolic proteins targeted for degradation to the lysosome (Kaushik & Cuervo, 2012).”
• ER stress: Autophagy induction, inhibition and selection (2015, background): “In chaperone-mediated autophagy, targeted proteins reach the proteases of the lysosomal matrix by direct translocation across the lysosomal membrane with the help of LAMP2A (lysosomal-associated membrane protein 2A) and lysosomal HSPA8/hsc73/lys-HSC70.(69)”