Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation

By E. Chi, S. Krishnan, T. Randolph, J. Carpenter. Pharmaceutical Research, 2003

1,354 citations recorded by the source corpus.

Subfields: Food Science, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1fe8254dbf0dfdec10d9f0030258945ddfcaac1b

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In Materials Chemistry

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Citations in the corpus

Design of novel FN3 domains with high stability by a consensus sequence approach. (2012, background): “In the biopharmaceutical realm, thermal stability can have consequences on the formulation, storage conditions and susceptibility to aggregation of such products (Chen et al., 1994a,b; Tsai et al., 1998; Remmele et al., 1999; Chi et al., 2003; Abdul-Fattah et al., 2007; Kueltzo et al., 2008).”
Non-coding RNA: what is functional and what is junk? (2015, neutral): “The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, and in the decision to publish the results.”
Challenges in the development of high protein concentration formulations. (2004, background): “Irreversible aggregation by noncovalent association generally occurs via hydrophobic regions exposed by thermal, mechanical, or chemical processes that alter a protein’s native conformation ( Chi et al. 2003 ).”
Protein aggregation: pathways, induction factors and analysis. (2009, background): “A change in pH has a strong influence on the aggregation rate as the pH determines the electrostatic interactions through charge distribution on the protein surface.(74) Under acidic conditions protein cleavage may occur, whereas under neutral to alkaline conditions deamidation and oxidation are fav”
Stability of Protein Pharmaceuticals: An Update (2010, background): “Some excellent overviews are available on the topic and make for excellent reading (296,316,317).”