Stability of Protein Pharmaceuticals: An Update

By M. Manning, Danny K. Chou, B. Murphy, Robert W. Payne, D. Katayama. 2010

1,067 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmaceutical Science, Radiology, Nuclear Medicine and Imaging

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Michele Vendruscolo
2. Pietro Sormanni
3. F. Aprile

In Radiology, Nuclear Medicine and Imaging

1. Michele Vendruscolo
2. Pietro Sormanni
3. F. Aprile

Citations in the corpus

• The CamSol method of rational design of protein mutants with enhanced solubility. (2015, background): “More generally, insufficient solubility represents a major bottleneck for the development of protein-based drugs, as protein aggregates not only are non-functional but also can be toxic and may elicit an immune response in the patient [14,28].”
• Pharmacokinetic aspects of retinal drug delivery. (2017, positive): “Protein stability involves physical phenomena and conformation changes that are not relevant for small molecules (Manning et al., 2010).”