Design of novel FN3 domains with high stability by a consensus sequence approach.

By S. Jacobs, M. Diem, Jinquan Luo, A. Teplyakov, G. Obmolova, T. Malia, Gary Gilliland, K. O'Neil. 2012

75 citations recorded by the source corpus.

Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging

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In Molecular Biology

1. Victor J. Torres
2. Francis Alonzo
3. Benjamin T. Porebski
4. Ashley M. Buckle

Citations in the corpus

• Consensus protein design (2016, background): “Although alfacon-1 is the only reported experimental study of immunogenicity for a consensus-designed protein, computational predictions using FN3 domains suggest that Tencon is also of low immunogenic potential (Jacobs et al., 2012).”
• Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus (2019, background): “Here, we describe studies that explore the potential of antibody mimetics known as centyrins, which have been explored in a number of clinical contexts (18, 19, 28, 41), to inhibit S.”