The case for rejecting the amyloid cascade hypothesis

By Karl Herrup. Nature Neuroscience, 2015

734 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/1f8dc6d0b699a954b4c3f6002c0873e02260a451

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Claudio Franceschi
2. M. Conte
3. Daniela Monti
4. Andrea Grignolio
5. Bradley T. Hyman
6. Paolo Garagnani
7. A. Santoro
8. M. Capri

In Physiology

1. Claudio Franceschi
2. V. Perry
3. M. Conte
4. Daniela Monti
5. Andrea Grignolio
6. Bradley T. Hyman
7. Paolo Garagnani
8. A. Santoro

Citations in the corpus

• The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “The limits of the current conceptualization on AD pathogenesis and of the amyloid cascade hypothesis are well summarized by two Nature Neuroscience papers released in 2015 (131, 132).”
• Oxidative stress and the amyloid beta peptide in Alzheimer’s disease (2017, background): “early 1990s [31–34] has become a dominant model for AD pathogenesis [35], although still controversial [36,37].”
• The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019, background): “This has caused severe criticism on the amyloid cascade hypothesis for AD, raising questions about its validity in sporadic AD (Behl and Ziegler, 2017; Harrison and Owen, 2016; Herrup, 2015; Karran and Hardy, 2014; Makin, 2018; Selkoe and Hardy, 2016).”