The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
By David Altshuler, Joel Hirschhorn, M. Klannemark, C. Lindgren, M. Vohl, J. Nemesh, C. R. Lane, S. Schaffner, S. Bolk, C. Brewer and 6 more. Nature Genetics, 2000
1,189 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/1f85ded1b8f84e0122cdfe3d8cb5cd59a383d23f
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In Molecular Biology
- D. Moller
- Nick Patterson
- David Reich
- Pardis C Sabeti
- Mark I. McCarthy
- Anthony J. Cesare
- Kenneth S. Kendler
- David J. Loane
In Physiology
Citations in the corpus
- Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. (2002, background): “Another example from type 2 diabetes is the frequent PPAR-g Pro12Ala polymorphism, for which a meta-analysis of 13,000 individuals was necessary to resolve apparently conflicting studies (Altshuler et al. 2000b).”
- The human ATP-binding cassette (ABC) transporter superfamily. (2001, neutral): “Scandinavian cohort (Altshuler et al. 2000).”
- Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. (2003, methodology): “The only other familial association study (4) showed a similar nonsignificant trend.”