Heat-shock protein 70 antagonizes apoptosis-inducing factor

By L. Ravagnan, S. Gurbuxani, S. Susin, C. Maisse, E. Daugas, N. Zamzami, T. Mak, M. Jäättelä, Josef M. Penninger, C. Garrido and 1 more. Nature Cell Biology, 2001

891 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1f34b994536a123bc71dbb60e1e14800454407ae

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In Molecular Biology

1. Guido Kroemer
2. Simone Fulda
3. M. Soengas
4. K. Ferri
5. Scott W. Lowe
6. O. Carnevali
7. H. Beere
8. A. Gorman

Citations in the corpus

• `The stress of dying': the role of heat shock proteins in the regulation of apoptosis (2004, background): “Apaf-1-independent cell death represents another distinct form of cell death that may or may not involve caspase activation (Jaattela and Tschopp, 2003; Lockshin and Zakeri, 2002) and is also regulated by Hsp70 (Ravagnan et al., 2001).”
• Apoptosis and melanoma chemoresistance (2003, background): “In addition to its role in controlling the folding of different cellular proteins involved in cell cycle and apoptosis (King et al., 2001; Peng et al., 2001), Hsp70 antagonizes the caspase-independent apoptotic inducer factor AIF (Ravagnan et al., 2001).”
• Live microbial feed supplement in aquaculture for improvement of stress tolerance (2006, background): “HSP70 is known also to be an anti-apoptotic factor: its expression level can determine the fate of the cell in response to a stress stimulus (Beere et al. 2000; Saleh et al. 2000; Ravagnan et al. 2001; Garrido et al. 2001).”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “Hsp70 can also interact with and inhibit apoptosis-inducing factor (AIF) thus inhibiting apoptotic nuclear changes [116, 117].”
• Organelle-specific initiation of cell death pathways (2001, background): “Heat shock proteins are also induced by a wide array of stress signals and act on multiple levels, by neutralizing stress signals (for example, through an interaction of Hsp70 with JNK-1), by suppressing caspase activation (for example, through interactions of Hsp27 with cytochrome c , Hsp70 with A”