Follicular helper CD4 T cells (TFH).

By Shane Crotty. Annual Review of Immunology, 2011

2,803 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1efa08db95a7012e608ba85078684cb05ca61434

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Citations in the corpus

T follicular helper cell biology: A decade of discovery and diseases (2019, background): “More encyclopedic reviews of TFs involved in Tfh differentiation are available (Crotty, 2011; Vinuesa et al., 2016).”
Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses (2013, neutral): “Nevertheless, we examined whether these activated ICOS+PD-1+++ cells were associated with HIV bnAb development.”
T Cell Dysfunction in Cancer (2018, background): “While its secretion by CD4+ follicular helper T cells has been well described (Crotty, 2011; Kroenke et al., 2012), its role in intratumoral CD8+ T cells is presently unknown.”
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. (2013, positive): “Expression of the surface receptor genes characteristic for Tfh cells ( CD200 and PDCD1 ) (41) and Th1/ activated T cells ( CD38 ) (42) correlated best with CXCL13 gene expression in the CD4 + TIL.”
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “CD4+ T cells can differentiate into multiple helper T cell populations upon antigen exposure, including Th1, Th2, Th9, Th17, and Tfh cells (Crotty, 2011; Jabeen and Kaplan, 2012; Littman and Rudensky, 2010; Paul and Zhu, 2010; Szabo et al., 2003) (Figure 5).”
Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “Interstitial DCs can either act directly on B cells (Dubois et al., 1997) or prime CD4+ T cells to differentiate into T follicular helper (Tfh) cells that help B cell differentiation in germinal centers (GCs) (Crotty, 2011).”
Bcl6 dependent T follicular helper cell differentiation diverges from effector cell differentiation during priming and depends on the gene Icos (2011, positive): “Previous studies have shown that Tfh cells are a distinguishable cell type in vivo required for germinal center development and that the emergence of Tfh cells is fully dependent on Bcl6 expression (Crotty, 2011).”