Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.

By M. Gillison, W. Koch, Randolph B. Capone, M. Spafford, W. Westra, Li Wu, Marianna Zahurak, R. Daniel, M. Viglione, D. Symer and 2 more. Journal of the National Cancer Institute, 2000

3,171 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Otorhinolaryngology

View Paper: https://www.semanticscholar.org/paper/1ec4cca9d004326b1d56bcf2ac038b10010d367c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Jemal
2. R. Siegel
3. Silvia Franceschi
4. G. Clifford
5. Elizabeth E. Ward
6. X. Castellsagué
7. E. Engels
8. Ruud H. Brakenhoff

In Genetics

1. humAn cArcinogens
2. Iarc Monographs
3. A. Jemal
4. peRsonAl hAbIts
5. R. Siegel

In Otorhinolaryngology

1. E. Engels
2. X. Castellsagué

Citations in the corpus

• A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen (2007, background): “However, these methods are extremely sensitive and can even detect a few DNA copies per sample, which might yield false-positive results.(4,10,17) Moreover, HPV-DNA presence does not per se indicate viral involvement in the carcinogenic process and may reflect a transient infection that does not car”
• High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. (2006, background): “HPV status and the type of treatment was not specifically addressed.(12,14,17,18)”
• Cancers with increasing incidence trends in the United States: 1999 through 2008 (2012, result): “Reasons for these increasing rates are unclear, but changing sexual practices (including oral-genital sexual contact) are hypothesized to be important.(9,13,15) The most dramatic increase in rates was among men ages 55 to 64 years, which is consistent with changes in HPV exposure patterns for men bo”
• Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. (2003, background): “HPVassociated cancers of the oral cavity and oropharynx are more likely to have basaloid histologic features ( 9 ,33), an aspect we did not evaluate.”
• The molecular biology of head and neck cancer (2011, background): “Later studies revealed that HPV-16 in particular is involved in HNSCC, the presence of the virus is particularly common in oropharyngeal tumours, and that tumours with HPV were associated with a more favourable clinical outcom”
• Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review (2005, background): “Nonetheless, the fact that HPV16 and HPV18 accounted for almost all oncogenic HPV types detected in HNSCC biopsies suggests that newly developed prophylactic vaccines for cervical cancer (31) should also be relevant for HNSCCs.”
• Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma (2013, background): “3 INTRODUCTION Human papillomavirus (HPV) is recognized as the causative agent of a growing subset of head and neck cancers (1, 2).”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Studies have shown that the prevalence of HPV DNA is negatively correlated with tobacco smoking and alcoholic beverage consumption (Gillison et al., 2000), suggesting that positive confounding by HPV is”
• Oral cavity and oropharyngeal squamous cell carcinoma—an update (2015, background): “Molecular evidence in support of HPV-driven HN-SCC includes the following observations: 1) high-risk, tumorigenic HPV-16 is present in 90% of HPV-positive HNSCCs; 2) in situ hybridization demonstrates localization of HPV-16 within the nuclei of HN-SCC cells; 3) HPV-16 DNA is present in high copy num”