Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

By B. Keele, E. Giorgi, J. Salazar-Gonzalez, J. Decker, Kimmy T. Pham, M. Salazar, Chuanxi Sun, T. Grayson, Shuyi Wang, Hui Li and 27 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,996 citations recorded by the source corpus.

Subfields: Hepatology, Infectious Diseases, Virology

View Paper: https://www.semanticscholar.org/paper/1e961ad161cb78512093e38a139d41e6a1bc4f4b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. John C. Mingers
2. Leroy White

In Virology

1. Beatrice H. Hahn
2. John C. Mingers
3. Leroy White

Citations in the corpus

• HIV-1 accessory proteins--ensuring viral survival in a hostile environment. (2008, background): “…sequence diversification that could, for instance, facilitate escape from adaptive immunity or help drive phenotypic changes in the virus: indeed, detailed analyses of recently transmitted viruses indicate that A3G/F can contribute to singlenucleotide sequence variation (Keele et al., 2008).”
• The immune response during acute HIV-1 infection: clues for vaccine development (2009, background): “Single-genome amplification and sequencing of the first detectable virus has shown that ∼80% of mucosally transmitted HIV-1 clade B and C infections are initiated by a single viru”
• Mucosal Immunity in the Female Genital Tract, HIV/AIDS (2014, background): “The founder strain is a single virus variant that usually initiates the infection with HIV, despite the presence of thousands of genetically diverse viral strains in the transmitting partner [190, 209, 210].”
• Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia (2008, methodology): “9021) by single-genome amplification (35).”
• HIV: cell binding and entry. (2012, background): “With rare exception, only R5 and R5X4 viruses are transmitted between individuals (Keele et al. 2008), likely owing to multiple imperfect but overlapping host restrictions on X4 HIV transmission (reviewed in Margolis and Shattock 2006).”
• Profound early control of highly pathogenic SIV by an effector-memory T cell vaccine (2011, neutral): “…against the smaller, localized and less diverse viral populations present in the first hours and days of mucosally acquired HIV/SIV infection 2,4,7,8 , we hypothesized that a vaccine able to “pre-position” differentiated effector cells (T EM ) at such early replication sites would demonstrate…”