Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

By T. Matsui, D. Leung, Hiroki Miyashita, I. Maksakova, Hitoshi Miyachi, H. Kimura, M. Tachibana, M. Lorincz, Y. Shinkai. Nature, 2010

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Induced pluripotency: history, mechanisms, and applications. (2010, background): “…are usually silenced toward the end of reprogramming (Stadtfeld et al. 2008b), due to the activation of both DNA (Lei et al. 1996) and histone (Matsui et al. 2010) methyltransferases, this process is often incomplete, resulting in partially reprogrammed cell lines that continue to depend on…”
KRAB zinc finger proteins (2017, background): “At sequences derived from TEs, this allows for the taming of transcriptional influences that would otherwise hamper early development, from zygotic genome activation to the establishment and normal differentiation of pluripotent stem cells (Rowe et al., 2010; Matsui et al., 2010; Rowe et al., 2013; ”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “…retroviral transgenes are usually silenced by DNA and histone methyltransferases towards the end of the reprogramming process (Lei et al., 1996; Matsui et al., 2010; Stadtfeld et al., 2008a), incomplete silencing can lead to partially reprogrammed cells that fail to activate endogenous…”