Virus-encoded proteinases and proteolytic processing in the Nidovirales.

By J. Ziebuhr, E. Snijder, Alexander E. Gorbalenya. Journal of General Virology, 2000

1,018 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Ecology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/1e3d8f7db4bff3ac91f0fc62abe50d5eba38f575

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Animal Science and Zoology

1. Yu Chen
2. Qianyun Liu
3. D. Guo
4. S. Perlman
5. P. Masters
6. Rolf Hilgenfeld
7. Ralph S. Baric
8. E. Snijder

In Ecology

1. Qianyun Liu
2. Yu Chen
3. D. Guo
4. Philippe Lemey

In Infectious Diseases

1. P. Masters
2. Yu Chen
3. Qianyun Liu
4. D. Guo
5. Rolf Hilgenfeld
6. Ralph S. Baric
7. S. Perlman
8. E. Snijder

Citations in the corpus

• Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV (2020, background): “Two proteases that participate in this proteolysis process are the coronavirus main proteinase (3CLpro) and the papain-like protease (PLpro).(5) In order to replicate the RNA genome, the CoV encodes a replicase that is an RNA-dependent RNA polymerase (RdRp).”
• Emerging coronaviruses: Genome structure, replication, and pathogenesis (2020, positive): “These polypeptides are processed by virally encoded chymotrypsin‐like protease (3CL) or main protease (M) and one or two papain‐like protease into 16 nsps.(10,11) Other ORFs on the one‐third of the genome near the 3′‐ terminus encodes at least four main structural proteins: spike (S),”
• Nidovirales: Evolving the largest RNA virus genome (2006, background): “Although little is known about the absolute time scale of nidovirus evolution, it w v c 1 e q t s r b t d a r n b 1 m e m y d a 1 i m a a d coronaviruses, since the PLpros of these two nidovirus branches do not seem to interleave with each other (Ziebuhr et al., 2000; Ziebuhr et al., 2001).”
• Human Coronavirus: Host-Pathogen Interaction. (2019, background): “Importantly, the RNA-dependent RNA polymerase (RdRP) activity is encoded in nsp12 (130), whereas papain-like protease (PLPro) and main protease (Mpro) activities are encoded in nsp3 and nsp5, respectively (149).”
• Coronavirus Genome Structure and Replication (2005, background): “It remains to be determined what enzyme functions to cap the viral RNAs (Ziebuhr et al. 2000).”
• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein (2017, background): “Nsp3 is released from pp1a/1ab by the papain-like protease domain(s), which is (are) part of Nsp3 itself (Fig. 1A; Ziebuhr et al., 2000).”
• Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain (2002, background): “This gene encodes two replicative polyproteins, pp1a (447 kDa) and pp1ab (754 kDa) that are processed by virus-encoded proteinases to produce the functional subunits of the replication complex (reviewed in Ziebuhr et al., 2000).”
• Coronaviruses: An Overview of Their Replication and Pathogenesis (2015, background): “These polyproteins are subsequently cleaved into the individual nsps [ 35 ].”
• SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum (2008, background): “[23,42], the viral main protease nsp5 [43], and the nsp8”
• Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event (2005, background): “The amino-terminal part of the polyprotein is predicted to be cleaved by the papain-like proteases (68), while the carboxyterminal part is putatively processed by the main coronavirus protease, 3CL (67).”
• The Molecular Biology of Coronaviruses (2006, background): “The efficiency of cleavage at particular polyprotein sites may be regulated by both the exact primary sequence at the site and the site’s accessibility to the proteinase (Ziebuhr, 2005; Ziebuhr et al., 2000).”
• Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage (2003, background): “A detailed comparison of the SARS-CoV replicase with that of its closest known relatives in group 2, mouse hepatitis coronavirus (MHV) and BCoV (Figure 1), revealed a replicase proteolytic processing scheme and domain organization that, with some notable exceptions (see below), proved to be typical ”