Thyroid hormone action is disrupted by bisphenol A as an antagonist.

By K. Moriyama, T. Tagami, T. Akamizu, T. Usui, M. Saijo, N. Kanamoto, Y. Hataya, A. Shimatsu, H. Kuzuya, K. Nakao. Journal of Clinical Endocrinology and Metabolism, 2002

822 citations recorded by the source corpus.

Subfields: Genetics, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/1da5395a7cb24c52fad819db243c24001aa07c25

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. E. Diamanti-Kandarakis
2. J. Mclachlan

In Health, Toxicology and Mutagenesis

1. J. Rochester
2. Cristina Casals-Casas
3. J. Heindel
4. B. Desvergne

Citations in the corpus

• Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “ER (416), BPA also binds to and antagonizes T3 activation of the TR (412, 417) with a Ki of approximately 10 4 M.”
• Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention (2019, background): “Similarly, BPA is an estrogen agonist, but also antagonizes thyroid hormone receptor [219].”
• Prenatal environmental exposures, epigenetics, and disease (2011, neutral): “Cell-based assays suggest that BPA blocks expression of TRβ [167,168].”
• Endocrine disruptors: from endocrine to metabolic disruption. (2011, background): “BPA may also act as an antagonist of the TR pathway by enhancing recruitment of the corepressor NCoR to TR (92).”
• Bisphenol A and human health: a review of the literature. (2013, background): “It has been shown that BPA and its halogenated derivatives may have both 15 agonistic and antagonistic interactions with the thyroid receptor [9, 147-149], which may explain 16 the complex outcomes reported in the human studies.”
• Endocrine Disrupting Chemicals and Disease Susceptibility (2011, background): “For example, one study found that BPA binds to the thyroid hormone receptor (TR) with a lower affinity than the estrogen receptor [10].”
• In vitro molecular mechanisms of bisphenol A action. (2007, background): “[36], an agonistic or antagonistic action of BPA on the TR in this system was not observed.”
• Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds. (2005, background): “Moriyama et al. (2002) reported that BPA acts as an antagonist of the thyroid hormone action of T3.”