Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

By Matthew D. Anway, A. Cupp, M. Uzumcu, Michael K. Skinner. Science, 2005

2,365 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1d64d77ba2bcb104fd025afec389fb5900ba896c

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Citations in the corpus

Epigenetics and the environment: emerging patterns and implications (2012, background): “Intriguingly, on paternal inheritance, part of this phenotype is iterated in males of subsequent generations, up to the third generatio”
Transgenerational Epigenetic Inheritance: myths and mechanisms (2014, neutral): “For example, outbred rats exposed to the fungicide vinclozolin in utero exhibited diminished male fertility over three to four generations of offspring, transmitted through the male germline (Anway et al., 2005).”
Endocrine Disrupting Chemicals and Disease Susceptibility (2011, background): “Interestingly, the transgenerational phenotypes observed in the animals also included adult onset diseases, such as kidney disease, immune abnormalities, prostate lesions and cancer [74, 76].”
Phenotypic plasticity and the epigenetics of human disease (2007, background): “Oestrogenic and anti-androgenic toxins that decrease male fertility alter DNA methylation, and these changes are inherited by subsequent generation”
Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (2010, background): “Treatment of pregnant rat mothers with the endocrine disruptor vinclozolin results in decreased fertility and behavorial changes in several generations of offspring (Anway et al., 2005; Crews et al., 2007).”
Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “The F1 vinclozolin male offspring developed latent disease in adulthood, consistent with the developmental basis of adult disease (35).”
Inherited epigenetic variation — revisiting soft inheritance (2006, background): “A recent publication reported that treatment of gestating female rats with industrial chemicals that disrupt endocrine function can lead to male fertility defects in subsequent generations (F1 to F4), which are correlated with widespread alterations in DNA methylatio”
Epigenetics for ecologists. (2007, background): “In mice, environmental toxins (Anway et al. 2005; Crews et al. 2007) and dietary supplements (Cropley et al. 2006) induce changes in DNA methylation that are inherited over several generations.”
Nongenetic Inheritance and Its Evolutionary Implications (2009, background): “…disruptors during the period of embryonic sex determination resulted in low fertility and high incidence of cancer and other diseases in male offspring, and this phenotype was transmitted through the male line for at least four generations (Anway & Skinner 2006; Anway et al. 2005, 2006).”
Soft inheritance: challenging the modern synthesis (2008, positive): “For example, Anway and his colleagues (Anway et al., 2005, 2006a, 2006b) injected pregnant females with vinclozolin (an anti-androgenic endocrine disruptor) during a sensitive period 8-15 days post coitum, and showed that the consequent abnormalities in male offspring were inherited for at least…”