The menthol receptor TRPM8 is the principal detector of environmental cold

By D. Bautista, J. Siemens, J. Glazer, Pamela R. Tsuruda, A. Basbaum, C. Stucky, S. Jordt, D. Julius. Nature, 2007

1,315 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/1d4792e1ff167946678b5a8e348eb4d5b312c6a9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. D. Julius
2. A. Basbaum
3. David J. Anderson
4. Arne May
5. Clifford J. Woolf
6. Ardem Patapoutian
7. R. Medzhitov

In Nutrition and Dietetics

1. D. Julius
2. A. Basbaum

In Sensory Systems

1. D. Julius
2. A. Basbaum
3. P. Goadsby
4. David J. Anderson
5. Arne May
6. Clifford J. Woolf
7. Ardem Patapoutian
8. R. Medzhitov

Citations in the corpus

• cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila (2008, neutral): “elegans, mice, and cultured cells [6–12].”
• TRP Channels (2012, neutral): “In particular, Trpm8 knockout mice had remarkable impairments in thermal responses in the temperature range between 15 and 30◦C and lacked sensitivity to icilin (32,71,85).”
• Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “While LRP1 encodes a lipoprotein involved in nociceptive glutamatergic signaling (147), TRPM8 encodes a cold-sensitive calcium channel that may induce burning pain (84, 592, 656).”
• Methods Used to Evaluate Pain Behaviors in Rodents (2017, background): “…test has been used extensively in the study of the role of thermosensitive transient receptor potential (TRP) channels in thermal nociception including TRPA1, TRPM8, TRPM3, TRPV3 and TRPV4 (Bautista et al., 2007; Knowlton et al., 2010; Huang et al., 2011; Vriens et al., 2011; Touska et al., 2016).”
• TRP channels and pain. (2013, background): “A subset of these TRPM8-positive cells may coexpress TRPV1 (with estimates ranging from 0–30% depending on detection strategy) (Bautista et al. 2007, Dhaka et al. 2008, Kobayashi et al. 2005, Mishra et al. 2011, Takashima et al. 2010) and/or CGRP, but a substantial fraction of these neurons are not…”
• Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli (2009, methodology): “WT and MrgprdDTR mice were individually housed at least 1 week before testing, which was performed blind to genotype and treatment group during the animals’ light period, as described previously (26, 40, 41).”