The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite ‘scavenger’?

By M. Whiteman, J. Armstrong, Siew Hwa Chu, Siau Jia-Ling, B. Wong, N. Cheung, Barry Halliwell, P. Moore. Journal of Neurochemistry, 2004

612 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria (2010, positive): “H2S also protects cells from cytotoxicity caused by peroxynitrite, b-amyloid, and hypochlorous acid (31, 51, 57, 58).”
Hydrogen sulfide and cell signaling. (2011, background): “Notwithstanding these biochemical means for H2S catabolism, H2S is a powerful reducing agent and is likely to be consumed by endogenous oxidant species in the vasculature, such as peroxynitrite (18), superoxide (19), and hydrogen peroxide (20).”
Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure (2017, positive): “H 2 S is also a powerful reducing agent and is mainly consumed by endogenous oxidants such as per-oxynitrite, superoxide, and hydrogen peroxide in the vascular system (25,51,166).”
Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation (2006, background): “H2S can scavenge peroxynitrite (4) and can interfere with the ability of”
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “H2S significantly inhibited ONOO -mediated toxicity and tyrosine nitration at concentrations well within the physiologically relevant levels (1, 306, 214, 700).”
Redox chemistry of biological thiols (2010, background): “H2S reacts rapidly with ONOOH, H2O2, lipid peroxides, and HOCl ([226–228] and P.”