The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

By Adam J Pawson, J. Sharman, H. E. Benson, E. Faccenda, Stephen P. H. Alexander, O. Buneman, A. Davenport, John C. McGrath, John A. Peters, C. Southan and 4 more. Nucleic Acids Res., 2013

932 citations recorded by the source corpus.

The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS ‘Guide to Receptors and Channels’ (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the ∼6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques.

Subfields: Computational Theory and Mathematics, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/1d426350e060cc7dc87562f671cd521fbdfd8387

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Citations in the corpus

DGIdb 2.0: mining clinically relevant drug–gene interactions (2015, methodology): “The largest source of new content was imported from the IUPHAR/BPS Guide To Pharmacology (GTP) (6), accounting for 10 225 interaction claims and 1,969 druggable gene category claims.”
Generic GPCR Residue Numbers - Aligning Topology Maps Minding The Gaps (2014, methodology): “NC-IUPHAR, together with its database Guide-ToPharmacology [76], will be working closely with GPCRDB to encourage acceptance of this system by the wider GPCR community.”
Machine learning approaches and databases for prediction of drug–target interaction: a survey paper (2020, methodology): “Similar to ChEMBL [ 237–239], IntAct [240] is a database that contains molecular interactions and can be used for drug research.”
ChemProt-3.0: a global chemical biology diseases mapping (2016, neutral): “We updated all the chemical protein interactions data from the open source databases ChEMBL (version 19) (4), BindingDB (17), PDSP Ki database (18), DrugBank (version 4) (19), PharmGKB (20), IUPHAR-DB database (21) and STITCH (version 4) (22).”
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions (2017, neutral): “First, we chose genes with corresponding drugs in TTD 26 , DrugBank 27 , or IUPHAR/BPS 28 .”
Network-based prediction of drug combinations (2019, methodology): “Speci ﬁ cally, bioactivity data of drug – target pairs were collected from three widely used databases: ChEMBL (v20, accessed in December 2015) 43 , BindingDB (downloaded in December 2015) 44 , and IUPHAR/BPS Guide to PHARMACOLOGY (downloaded in December 2015) 45 .”
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins (2016, methodology): “First, we extracted known GPCR-ligand interactions from the Guide to Pharmacology (52).”
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor (2015, neutral): “TARGETS LIGANDS GPCRs 2-AG, 2-arachidonylglycer CB1 receptors AM251 CB2 receptors CBD, cannabidiol ORG27569 THC, Δ9-tetrahydrocanna These Tables list key protein targets and ligands in this article which are hyperlinked t guidetopharmacology.org, the common portal for data from the IUPHAR/BPS Guide ”
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands (2015, background): “Content changes since our 2014 publication (6).”
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY (2017, background): “From 2012 to 2015, the scope expanded to define the data-supported druggable genome and the resource was re-named GtoPdb (4,5).”