NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

By Mamoru Ito, H. Hiramatsu, Kimio Kobayashi, K. Suzue, Mariko Kawahata, K. Hioki, Y. Ueyama, Y. Koyanagi, K. Sugamura, K. Tsuji and 2 more. Blood, 2002

1,436 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/1d12e2fe12aac031508946052f5787e687486101

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In Immunology

1. J. Dick
2. A. Haase
3. S. Morrison
4. B. Welm

In Oncology

1. S. Morrison
2. J. Dick
3. Mark Shackleton
4. E. Quintana
5. B. Welm
6. Jane E. Visvader
7. Hans Clevers
8. K. Polyak

Citations in the corpus

• Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized (2010, background): “For these reasons, 30 years of research has found that the preferred system for studying the potential of normal human hematopoietic stem cells (Ito et al., 2002; Shultz et al., 2005) and human leukemic stem cells (Agliano et al.”
• Hematopoiesis: a human perspective. (2012, methodology): “To circumvent this problem, NOD-scid mice with either truncation (NOG) or a deletion in the IL-2R common g chain (NSG), a critical component for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 signaling, were developed (Ito et al., 2002; Shultz et al., 2005).”
• Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes (2011, background): “have reported successful engraftment of primary tumors in more severely immunocompromised mice (the double mutant NOD-SCID Il2rg −/− (NSG) mice, which lack natural killer cells as well as mature lymphocyte”
• Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1 (2006, background): “The single common denominator in all these recently described systems is that the selection of the human T-cell repertoire is believed to take place in the context of the mouse MHC in the mouse thymu”
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “To compare the functional HSC activity of d-HSCs (LRC HSCs) with a-HSCs (LRC HSCs), 50 cells of either phenotype were FACS sorted and transplanted into lethally irradiated NOD/SCID/gc mice (Ito et al., 2002).”
• Humanized mice in translational biomedical research (2007, background): “The third breakthrough was the humanization of immunodeficient mice homozygous for targeted mutations at the interleukin-2 receptor (IL-2R) γ-chain locus ( Il2rg ; also known as the common cytokine-receptor γ-chain, γc”